Hello! I'm the co-founder and brand strategist of Motto, a brand strategy and design firm. We help companies launch, grow and reinvent their brands and build CMS, responsive websites using ExpressionEngine and Wordpress for our clients. I'm wondering if you could provide a bit more detail for me regarding your question so I can best help you. With regards to best technology to design a website, can you elaborate on what the purpose of the site is and are you looking for a platform to build it on or primarily a way to design the site itself? That will help me determine how to give you the best recommendations. Look forward to hearing from you!
That really depends on the website that you're trying to build. More often than not, I'd recommend a well supported CMS - WordPress, Joomla, Drupal, etc. but agin, it really depends on the type of site you're building.
The technology to design is perhaps the wrong question. Are you asking the best development tool or the best system to manage your content and shopping cart?
Technology is just a means to and end, it's often the road to where a problem lies.
Determine what is your problem and why do you need a website.