I am in HR and would want to make it location independent.
I've helped several businesses (including an HR consultancy) transition from local to nationwide clientele. If you already have a base of clients already, testimonials, client brand names, and case studies will help establish trust with remote prospects.
For long distance sales and marketing, partnerships are the best option - hands down. Identify complementary business models, and reach out to them. Offer a generous commission for any referral which turns into a sale (I tend to provide 20% for the lifetime of any referred client, although many people feel that is too generous).
In marketing, our best partners are web design firms - companies which make websites, apps, and graphics. They can build the world's most incredible website or app, but without successful marketing their clients won't see any bottom-line results. Once I walk through our system to build trust and rapport, we sign a contract and dip our feet in the water with their first referrals to us - then ramp it up to full speed.
I can help you get a system in place and running. It would take about 3 hours of phone calls - spaced out about a week apart between each call. Feel free to schedule something if you want to talk in depth and get it going. www.clarity.fm/ryandraving